Platelet Poor Plasma and Platelet Rich Plasma: What are the Differences?

Platelet poor plasma (PPP) and platelet rich plasma (PRP) are both used in regenerative medicine to speed up the natural healing process of the body. Both PPP and PRP come from a patient’s blood. They both have platelets and plasma and are made around the same way. The blood sample taken can be used by a doctor to create solutions of PRP and PPP. Depending on the patient’s needs, it is possible to make both PPP and PRP from the same sample.

What is PPP?

Platelet poor plasma does not have a lot of platelets. But doctors have discovered that PPP has unique healing properties. For example, PPP can be used in a procedure performed for freeing and relieving a trapped nerve. PPP treatment can also give relief to patients suffering from ulnar neuropathy and some kinds of carpal tunnel. Some doctors use PPP for healing damaged muscle tissue that used to be impossible to heal.

PPP is used as a scientific experimental control and serves as a mechanism for calibrating the concentration of platelet-rich plasma samples. Since it is believed to contain very high levels of fibrinogen, it has its own right as a healing agent. Fibrinogen is an agent that speeds up wound healing.

What is PRP?

PRP contains a higher concentration of platelets, which control clotting. Also, platelets release chemical signals to alert the body to the presence of an injury. Once alerted, the body will initiate a natural healing response. When injected at the injury site, the platelets evaluate and determine the presence of damage that must be fixed.

PRP has many uses because of its high concentration of growth factors. Such growth-enhancing chemicals are believed to speed up the process of tissue repair in the body. Platelets can ramp up the production of different kinds of fibroblasts, which is also an important factor in the healing process.

PRP has been used for reviving injured tendons, attract blood to injury sites, and help with new cell recruitment. Also, it has been found helpful in speeding up blood vessel growth, boosting the injury sites’ nutritional profile, and promoting healthful metabolic processes.


Neither PPP nor PRP is better than the other. The most important thing is to use the right solution to an issue. Depending on the pain’s exact cause, doctors may recommend PPP, PRP, or even a different treatment. When you visit a provider of these treatments, the doctor will help the patient find out which one is right for them.

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